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Assay Detail

CHEMBL1010085

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Binding
Inhibition of Escherichia coli FabH
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors.
Alhamadsheh MM, Waters NC, Sachdeva S, Lee P, Reynolds KA.
Bioorg Med Chem Lett (2008) 18 : 6402 -6405
PubMed 18996691 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.51 8.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL460104 1 8.06
CHEMBL445555 1 8.01
CHEMBL512926 1 7.93
CHEMBL509952 1 7.87
CHEMBL462374 1 7.81
CHEMBL462205 1 7.67
CHEMBL491752 1 7.06
CHEMBL455414 1 7.01
CHEMBL451059 1 6.95
CHEMBL454282 1 6.73
CHEMBL462375 1 -
CHEMBL462376 1 -
CHEMBL462553 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL460104 IC50 = 8.8 nM 8.06
CHEMBL445555 IC50 = 9.7 nM 8.01
CHEMBL512926 IC50 = 11.8 nM 7.93
CHEMBL509952 IC50 = 13.6 nM 7.87
CHEMBL462374 IC50 = 15.4 nM 7.81
CHEMBL462205 IC50 = 21.2 nM 7.67
CHEMBL491752 IC50 = 87.3 nM 7.06
CHEMBL455414 IC50 = 96.5 nM 7.01
CHEMBL451059 IC50 = 112.4 nM 6.95
CHEMBL454282 IC50 = 187.2 nM 6.73
CHEMBL462375 IC50 > 10000.0 nM -
CHEMBL462376 IC50 > 10000.0 nM -
CHEMBL462553 IC50 > 10000.0 nM -