Assay Detail
Binding
CHEMBL1010089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis FabH
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL3640) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.17 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509952 | — | — | 1 | 9.21 |
| CHEMBL462374 | — | — | 1 | 8.83 |
| CHEMBL454282 | — | — | 1 | 8.70 |
| CHEMBL462205 | — | — | 1 | 8.55 |
| CHEMBL445555 | — | — | 1 | 8.51 |
| CHEMBL491752 | — | — | 1 | 8.45 |
| CHEMBL455414 | — | — | 1 | 8.45 |
| CHEMBL460104 | — | — | 1 | 8.44 |
| CHEMBL512926 | — | — | 1 | 8.43 |
| CHEMBL451059 | — | — | 1 | 8.07 |
| CHEMBL462376 | — | — | 1 | 7.50 |
| CHEMBL462375 | — | — | 1 | 7.46 |
| CHEMBL501551 | — | — | 1 | 6.95 |
| CHEMBL462553 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509952 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL462374 | — | IC50 | = | 1.49 | nM | 8.83 |
| CHEMBL454282 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL462205 | — | IC50 | = | 2.84 | nM | 8.55 |
| CHEMBL445555 | — | IC50 | = | 3.09 | nM | 8.51 |
| CHEMBL491752 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL455414 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL460104 | — | IC50 | = | 3.61 | nM | 8.44 |
| CHEMBL512926 | — | IC50 | = | 3.76 | nM | 8.43 |
| CHEMBL451059 | — | IC50 | = | 8.47 | nM | 8.07 |
| CHEMBL462376 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL462375 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL501551 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL462553 | — | IC50 | = | 138.1 | nM | 6.86 |