Assay Detail
Binding
CHEMBL1010181
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Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.53 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462911 | — | — | 1 | 8.14 |
| CHEMBL462709 | — | — | 1 | 7.33 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462911 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL462709 | — | IC50 | = | 47.2 | nM | 7.33 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 74.5 | nM | 7.13 |