Assay Detail
Binding
CHEMBL1010201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of uPA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.18 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513339 | — | — | 1 | 5.52 |
| CHEMBL461441 | — | — | 1 | 5.50 |
| CHEMBL461016 | — | — | 1 | 5.44 |
| CHEMBL379194 | — | — | 1 | 5.44 |
| CHEMBL461870 | — | — | 1 | 5.43 |
| CHEMBL468894 | — | — | 1 | 5.43 |
| CHEMBL468270 | — | — | 1 | 5.42 |
| CHEMBL512118 | — | — | 1 | 5.28 |
| CHEMBL499274 | — | — | 1 | 5.21 |
| CHEMBL469090 | — | — | 1 | 5.18 |
| CHEMBL460810 | — | — | 1 | 5.16 |
| CHEMBL461440 | — | — | 1 | 5.09 |
| CHEMBL461655 | — | — | 1 | 5.08 |
| CHEMBL518179 | — | — | 1 | 5.07 |
| CHEMBL513007 | — | — | 1 | 5.06 |
| CHEMBL499200 | — | — | 1 | 5.02 |
| CHEMBL460378 | — | — | 1 | 5.00 |
| CHEMBL468895 | — | — | 1 | 4.96 |
| CHEMBL516786 | — | — | 1 | 4.96 |
| CHEMBL466588 | — | — | 1 | 4.92 |
| CHEMBL513818 | — | — | 1 | 4.92 |
| CHEMBL453766 | — | — | 1 | 4.85 |
| CHEMBL459525 | — | — | 1 | - |
| CHEMBL462253 | — | — | 1 | - |
| CHEMBL514449 | — | — | 1 | - |
| CHEMBL459507 | — | — | 1 | - |
| CHEMBL518010 | — | — | 1 | - |
| CHEMBL466585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513339 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL461441 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL461016 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL379194 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL461870 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL468894 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL468270 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL512118 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL499274 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL469090 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL460810 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL461440 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL461655 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL518179 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL513007 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL499200 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL460378 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL468895 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL516786 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL466588 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL513818 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL453766 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL459525 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL462253 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL514449 | — | Ki | - | — | - | |
| CHEMBL459507 | — | Ki | - | — | - | |
| CHEMBL518010 | — | Ki | - | — | - | |
| CHEMBL466585 | — | Ki | = | 129000.0 | nM | - |