Assay Detail
Functional
CHEMBL1010740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of H2O2-induced cell death in human WRL68 cells after 3 hrs by MTT assay
37
Total Activities
37
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WRL68 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New poly(ADP-ribose) polymerase-1 inhibitors with antioxidant activity based on 4-carboxamidobenzimidazole-2-ylpyrroline and -tetrahydropyridine nitroxides and their precursors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.71 | 8.03 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459797 | — | — | 1 | 8.03 |
| CHEMBL459362 | — | — | 1 | 7.48 |
| CHEMBL471847 | — | — | 1 | 7.10 |
| CHEMBL452112 | — | — | 1 | 7.02 |
| CHEMBL469960 | — | — | 1 | 7.01 |
| CHEMBL472471 | — | — | 1 | 7.00 |
| CHEMBL471640 | — | — | 1 | 6.72 |
| CHEMBL472470 | — | — | 1 | 6.62 |
| CHEMBL469959 | — | — | 1 | 6.49 |
| CHEMBL498925 | — | — | 1 | 6.48 |
| CHEMBL469752 | — | — | 1 | 6.47 |
| CHEMBL469961 | — | — | 1 | 6.32 |
| CHEMBL511457 | — | — | 1 | 6.21 |
| CHEMBL459994 | — | — | 1 | 5.79 |
| CHEMBL472264 | — | — | 1 | 5.79 |
| CHEMBL469750 | — | — | 1 | 5.70 |
| CHEMBL459796 | — | — | 1 | 5.50 |
| CHEMBL511273 | — | — | 1 | 5.50 |
| CHEMBL469751 | — | — | 1 | 5.47 |
| CHEMBL470378 | — | — | 1 | 5.46 |
| CHEMBL511458 | — | — | 1 | 5.40 |
| CHEMBL469533 | — | — | 1 | 5.25 |
| CHEMBL472472 | — | — | 1 | 5.16 |
| CHEMBL470166 | — | — | 1 | 5.09 |
| CHEMBL516617 | — | — | 1 | 5.00 |
| CHEMBL512143 | — | — | 1 | 4.95 |
| CHEMBL2094004 | — | — | 1 | 4.90 |
| CHEMBL518018 | — | — | 1 | 4.81 |
| CHEMBL2094005 | — | — | 1 | 4.68 |
| CHEMBL459568 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459797 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL459362 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL471847 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL452112 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL469960 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL472471 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL471640 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL472470 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL469959 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL498925 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL469752 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL469961 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL511457 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL459994 | — | IC50 | = | 1614.0 | nM | 5.79 |
| CHEMBL472264 | — | IC50 | = | 1614.0 | nM | 5.79 |
| CHEMBL469750 | — | IC50 | = | 1985.0 | nM | 5.70 |
| CHEMBL459796 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL511273 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL469751 | — | IC50 | = | 3347.0 | nM | 5.47 |
| CHEMBL470378 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL511458 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL469533 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL472472 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL470166 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL516617 | — | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL512143 | — | IC50 | = | 11141.0 | nM | 4.95 |
| CHEMBL2094004 | — | IC50 | = | 12670.0 | nM | 4.90 |
| CHEMBL518018 | — | IC50 | = | 15570.0 | nM | 4.81 |
| CHEMBL2094005 | — | IC50 | = | 20950.0 | nM | 4.68 |
| CHEMBL459568 | — | IC50 | = | 26760.0 | nM | 4.57 |
| CHEMBL472265 | — | IC50 | = | 28310.0 | nM | 4.55 |
| CHEMBL470583 | — | IC50 | = | 32010.0 | nM | 4.50 |
| CHEMBL459583 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL513251 | — | IC50 | = | 56660.0 | nM | 4.25 |
| CHEMBL513759 | — | IC50 | = | 60920.0 | nM | 4.21 |
| CHEMBL449266 | — | Activity | - | — | - | |
| CHEMBL472266 | — | Activity | - | — | - |