Assay Detail
Binding
CHEMBL1010815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PARP1
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.95 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521714 | — | — | 1 | 8.52 |
| CHEMBL495743 | — | — | 1 | 8.52 |
| CHEMBL525192 | — | — | 1 | 8.40 |
| CHEMBL495942 | — | — | 1 | 8.40 |
| CHEMBL526668 | — | — | 1 | 8.40 |
| CHEMBL488496 | — | — | 1 | 8.40 |
| CHEMBL521880 | — | — | 1 | 8.40 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 8.30 |
| CHEMBL497608 | — | — | 1 | 8.30 |
| CHEMBL498007 | — | — | 1 | 8.30 |
| CHEMBL521712 | — | — | 1 | 8.30 |
| CHEMBL488053 | — | — | 1 | 8.30 |
| CHEMBL527654 | — | — | 1 | 8.22 |
| CHEMBL497609 | — | — | 1 | 8.22 |
| CHEMBL495969 | — | — | 1 | 8.22 |
| CHEMBL498015 | — | — | 1 | 8.15 |
| CHEMBL488830 | — | — | 1 | 8.15 |
| CHEMBL495951 | — | — | 1 | 8.10 |
| CHEMBL506516 | — | — | 1 | 8.05 |
| CHEMBL498008 | — | — | 1 | 8.05 |
| CHEMBL450698 | — | — | 1 | 8.05 |
| CHEMBL496976 | — | — | 1 | 8.00 |
| CHEMBL522549 | — | — | 1 | 8.00 |
| CHEMBL507412 | — | — | 1 | 7.89 |
| CHEMBL495782 | — | — | 1 | 7.89 |
| CHEMBL504096 | — | — | 1 | 7.82 |
| CHEMBL525535 | — | — | 1 | 7.77 |
| CHEMBL445016 | — | — | 1 | 7.72 |
| CHEMBL497181 | — | — | 1 | 7.64 |
| CHEMBL495975 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521714 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL495743 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL525192 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL495942 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL526668 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL488496 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL521880 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL521712 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL488053 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL498007 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL497608 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL506871 | VELIPARIB | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL527654 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL497609 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL495969 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL498015 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL488830 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL495951 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL506516 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL450698 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL498008 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL496976 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL522549 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL507412 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL495782 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL504096 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL525535 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL445016 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL497181 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL495975 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL488831 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL497597 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL505909 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL523083 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL509153 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL495950 | — | Ki | = | 3300.0 | nM | 5.48 |