Assay Detail
Binding
CHEMBL1010816
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Inhibition of human recombinant PARP2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.46 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497608 | — | — | 1 | 8.70 |
| CHEMBL526668 | — | — | 1 | 8.70 |
| CHEMBL495942 | — | — | 1 | 8.70 |
| CHEMBL495743 | — | — | 1 | 8.40 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 8.30 |
| CHEMBL527654 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497608 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL526668 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL495942 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL495743 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL506871 | VELIPARIB | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL527654 | — | Ki | = | 11.0 | nM | 7.96 |