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Assay Detail

CHEMBL1010955

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Delta-9-desaturase in human HepG2 cells
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HepG2
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Stearoyl-CoA desaturase (CHEMBL5555) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors.
Koltun DO, Parkhill EQ, Vasilevich NI, Glushkov AI, Zilbershtein TM, Ivanov AV, Cole AG, Henderson I, Zautke NA, Brunn SA, Mollova N, Leung K, Chisholm JW, Zablocki J.
Bioorg Med Chem Lett (2009) 19 : 2048 -2052
PubMed 19249203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 7.36 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL494748 — — 1 10.30
CHEMBL521993 — — 1 8.55
CHEMBL494359 — — 1 8.51
CHEMBL494544 — — 1 8.49
CHEMBL493961 — — 1 8.48
CHEMBL522872 — — 1 8.25
CHEMBL522160 — — 1 8.19
CHEMBL493960 — — 1 8.07
CHEMBL495352 — — 1 8.02
CHEMBL494552 — — 1 7.89
CHEMBL495170 — — 1 7.89
CHEMBL494543 — — 1 7.89
CHEMBL495001 — — 1 7.82
CHEMBL523356 — — 1 7.80
CHEMBL523668 — — 1 7.80
CHEMBL495359 — — 1 7.68
CHEMBL495194 — — 1 7.47
CHEMBL494828 — — 1 7.44
CHEMBL522883 — — 1 7.40
CHEMBL494031 — — 1 7.33
CHEMBL494032 — — 1 7.33
CHEMBL522492 — — 1 7.29
CHEMBL495191 — — 1 7.09
CHEMBL524169 — — 1 7.04
CHEMBL493929 — — 1 7.02
CHEMBL494023 — — 1 7.00
CHEMBL495356 — — 1 6.96
CHEMBL521865 — — 1 6.92
CHEMBL493139 — — 1 6.92
CHEMBL494747 — — 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL494748 — IC50 = 0.05 nM 10.30
CHEMBL521993 — IC50 = 2.8 nM 8.55
CHEMBL494359 — IC50 = 3.1 nM 8.51
CHEMBL494544 — IC50 = 3.2 nM 8.49
CHEMBL493961 — IC50 = 3.3 nM 8.48
CHEMBL522872 — IC50 = 5.6 nM 8.25
CHEMBL522160 — IC50 = 6.5 nM 8.19
CHEMBL493960 — IC50 = 8.6 nM 8.07
CHEMBL495352 — IC50 = 9.6 nM 8.02
CHEMBL494552 — IC50 = 13.0 nM 7.89
CHEMBL495170 — IC50 = 13.0 nM 7.89
CHEMBL494543 — IC50 = 13.0 nM 7.89
CHEMBL495001 — IC50 = 15.0 nM 7.82
CHEMBL523668 — IC50 = 16.0 nM 7.80
CHEMBL523356 — IC50 = 16.0 nM 7.80
CHEMBL495359 — IC50 = 21.0 nM 7.68
CHEMBL495194 — IC50 = 34.0 nM 7.47
CHEMBL494828 — IC50 = 36.0 nM 7.44
CHEMBL522883 — IC50 = 40.0 nM 7.40
CHEMBL494031 — IC50 = 47.0 nM 7.33
CHEMBL494032 — IC50 = 47.0 nM 7.33
CHEMBL522492 — IC50 = 51.0 nM 7.29
CHEMBL495191 — IC50 = 81.0 nM 7.09
CHEMBL524169 — IC50 = 92.0 nM 7.04
CHEMBL493929 — IC50 = 96.0 nM 7.02
CHEMBL494023 — IC50 = 100.0 nM 7.00
CHEMBL495356 — IC50 = 110.0 nM 6.96
CHEMBL521865 — IC50 = 120.0 nM 6.92
CHEMBL493139 — IC50 = 120.0 nM 6.92
CHEMBL494747 — IC50 = 130.0 nM 6.89
CHEMBL494598 — IC50 = 140.0 nM 6.85
CHEMBL492498 — IC50 = 180.0 nM 6.75
CHEMBL493134 — IC50 = 210.0 nM 6.68
CHEMBL494827 — IC50 = 250.0 nM 6.60
CHEMBL494750 — IC50 = 410.0 nM 6.39
CHEMBL492976 — IC50 = 1670.0 nM 5.78
CHEMBL493333 — IC50 = 2500.0 nM 5.60
CHEMBL494583 — IC50 = 4000.0 nM 5.40
CHEMBL523207 — IC50 = 4600.0 nM 5.34
CHEMBL492392 — IC50 - — -
CHEMBL493746 — IC50 - — -
CHEMBL494402 — IC50 > 3000.0 nM -
CHEMBL494599 — IC50 - — -
CHEMBL494168 — IC50 - — -
CHEMBL495351 — IC50 - — -
CHEMBL494185 — IC50 - — -
CHEMBL493108 — IC50 - — -
CHEMBL492499 — IC50 - — -
CHEMBL492500 — IC50 - — -
CHEMBL522329 — IC50 - — -