Assay Detail
Binding
CHEMBL1011047
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Binding affinity to ROCK2 by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.07 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297394 | — | — | 1 | 8.85 |
| CHEMBL1315166 | — | — | 1 | 7.51 |
| CHEMBL501706 | — | — | 1 | 7.05 |
| CHEMBL505949 | — | — | 1 | 6.92 |
| CHEMBL498924 | — | — | 1 | 6.73 |
| CHEMBL495766 | — | — | 1 | 5.35 |
| CHEMBL525385 | — | — | 1 | - |
| CHEMBL524516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297394 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL1315166 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL501706 | — | Kd | = | 89.7 | nM | 7.05 |
| CHEMBL505949 | — | Kd | = | 119.0 | nM | 6.92 |
| CHEMBL498924 | — | Kd | = | 187.0 | nM | 6.73 |
| CHEMBL495766 | — | Kd | = | 4480.0 | nM | 5.35 |
| CHEMBL525385 | — | Kd | < | 1.0 | nM | - |
| CHEMBL524516 | — | Kd | < | 1.0 | nM | - |