Assay Detail
Binding
CHEMBL1011675
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Inhibition of human ERG td[wt:F656A] mutant expressed in HEK293 cells by whole cell patch clamp method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.74 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 8.00 |
| CHEMBL536480 | — | — | 1 | 7.70 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL536480 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 30.0 | nM | 7.52 |