Assay Detail
Binding
CHEMBL1011734
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Displacement of [125I]RTI55 from human recombinant DAT expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.55 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.43 |
| CHEMBL454507 | — | — | 1 | 5.57 |
| CHEMBL446084 | — | — | 1 | 5.44 |
| CHEMBL499461 | — | — | 1 | 5.35 |
| CHEMBL465123 | SEPROXETINE | 2.0 | 1 | 5.34 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.18 |
| CHEMBL313041 | — | — | 1 | - |
| CHEMBL480988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL454507 | — | Ki | = | 2716.0 | nM | 5.57 |
| CHEMBL446084 | — | Ki | = | 3661.0 | nM | 5.44 |
| CHEMBL499461 | — | Ki | = | 4492.0 | nM | 5.35 |
| CHEMBL465123 | SEPROXETINE | Ki | = | 4544.0 | nM | 5.34 |
| CHEMBL41 | FLUOXETINE | Ki | = | 6670.0 | nM | 5.18 |
| CHEMBL313041 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL480988 | — | Ki | > | 100000.0 | nM | - |