Assay Detail
Binding
CHEMBL1011763
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Inhibition of calpain-10 in rabbit mitochondrial matrix fractions by spectrofluorimetry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification and optimization of a novel inhibitor of mitochondrial calpain 10.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.78 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92708 | CALPEPTIN | — | 1 | 8.40 |
| CHEMBL502345 | — | — | 1 | 7.22 |
| CHEMBL511248 | — | — | 1 | 7.05 |
| CHEMBL517135 | — | — | 1 | 7.00 |
| CHEMBL450142 | — | — | 1 | 6.62 |
| CHEMBL443987 | — | — | 1 | 6.54 |
| CHEMBL468462 | — | — | 1 | 5.70 |
| CHEMBL461196 | — | — | 1 | 5.70 |
| CHEMBL518036 | — | — | 1 | - |
| CHEMBL461195 | — | — | 1 | - |
| CHEMBL462252 | — | — | 1 | - |
| CHEMBL462251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92708 | CALPEPTIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL502345 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL511248 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL517135 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL450142 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL443987 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL468462 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL461196 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL518036 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL461195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL462252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL462251 | — | IC50 | > | 100000.0 | nM | - |