Assay Detail
Binding
CHEMBL1011778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by Lineweaver-Burke plot in presence of NADPH
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.99 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513615 | — | — | 1 | 8.72 |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 8.66 |
| CHEMBL459503 | — | — | 1 | 8.25 |
| CHEMBL459502 | — | — | 1 | 8.19 |
| CHEMBL522733 | — | — | 1 | 7.88 |
| CHEMBL509750 | — | — | 1 | 7.82 |
| CHEMBL495567 | — | — | 1 | 7.59 |
| CHEMBL495565 | — | — | 1 | 7.48 |
| CHEMBL496777 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513615 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1444 | LETROZOLE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL459503 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL459502 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL522733 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL509750 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL495567 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL495565 | — | Ki | = | 33.4 | nM | 7.48 |
| CHEMBL496777 | — | Ki | = | 52.7 | nM | 7.28 |