Assay Detail
Binding
CHEMBL1012215
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Displacement of [3H]mesulergine form human cloned 5HT2C receptor expressed in african green monkey COS7 cells by scintillation spectroscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.12 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.89 |
| CHEMBL463249 | — | — | 1 | 6.48 |
| CHEMBL511879 | — | — | 1 | 5.64 |
| CHEMBL463250 | — | — | 1 | 5.46 |
| CHEMBL504264 | AUREOL | — | 1 | - |
| CHEMBL463442 | — | — | 1 | - |
| CHEMBL517151 | — | — | 1 | - |
| CHEMBL457256 | — | — | 1 | - |
| CHEMBL457078 | AUREOL ACETATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL463249 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL511879 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL463250 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL504264 | AUREOL | Ki | - | — | - | |
| CHEMBL463442 | — | Ki | - | — | - | |
| CHEMBL517151 | — | Ki | - | — | - | |
| CHEMBL457256 | — | Ki | - | — | - | |
| CHEMBL457078 | AUREOL ACETATE | Ki | - | — | - |