Assay Detail
Binding
CHEMBL1012269
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Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.97 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493263 | — | — | 1 | 7.30 |
| CHEMBL257424 | — | — | 1 | 7.30 |
| CHEMBL451165 | — | — | 1 | 7.30 |
| CHEMBL479783 | — | — | 1 | 7.16 |
| CHEMBL481306 | — | — | 1 | 6.89 |
| CHEMBL257423 | — | — | 1 | 6.75 |
| CHEMBL493040 | — | — | 1 | 6.70 |
| CHEMBL443922 | — | — | 1 | 6.54 |
| CHEMBL479999 | — | — | 1 | 6.37 |
| CHEMBL502129 | — | — | 1 | 6.29 |
| CHEMBL449015 | — | — | 1 | 6.28 |
| CHEMBL446481 | — | — | 1 | 6.20 |
| CHEMBL493264 | — | — | 1 | 6.19 |
| CHEMBL474922 | — | — | 1 | 6.17 |
| CHEMBL479410 | — | — | 1 | 6.16 |
| CHEMBL452376 | — | — | 1 | 6.12 |
| CHEMBL383706 | — | — | 1 | 6.11 |
| CHEMBL482292 | — | — | 1 | 5.98 |
| CHEMBL492842 | — | — | 1 | 5.89 |
| CHEMBL491268 | — | — | 1 | 5.89 |
| CHEMBL507422 | — | — | 1 | 5.85 |
| CHEMBL481526 | — | — | 1 | 5.82 |
| CHEMBL493057 | — | — | 1 | 5.70 |
| CHEMBL479411 | — | — | 1 | 5.70 |
| CHEMBL481124 | — | — | 1 | 5.57 |
| CHEMBL481696 | — | — | 1 | 5.54 |
| CHEMBL482293 | — | — | 1 | 5.52 |
| CHEMBL493476 | — | — | 1 | 5.51 |
| CHEMBL481695 | — | — | 1 | 5.38 |
| CHEMBL448689 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493263 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL451165 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL257424 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL479783 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL481306 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL257423 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL493040 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL443922 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL479999 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL502129 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL449015 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL446481 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL493264 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL474922 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL479410 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL452376 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL383706 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL482292 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL492842 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL491268 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL507422 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL481526 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL479411 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL493057 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL481124 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL481696 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL482293 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL493476 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL481695 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL448689 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL481697 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL493056 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL482295 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL481353 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL492841 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL451120 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL453493 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL493027 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL493058 | — | IC50 | - | — | - | |
| CHEMBL493667 | — | IC50 | - | — | - | |
| CHEMBL500629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL479409 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL520760 | — | IC50 | - | — | - | |
| CHEMBL482294 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL481527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL481941 | — | IC50 | - | — | - |