Assay Detail
Binding
CHEMBL1012290
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Inhibition of ovine CAPN1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.35 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524196 | — | — | 1 | 6.82 |
| CHEMBL494262 | — | — | 1 | 6.54 |
| CHEMBL521116 | — | — | 1 | 6.54 |
| CHEMBL494261 | — | — | 1 | 6.47 |
| CHEMBL482298 | — | — | 1 | 6.36 |
| CHEMBL521112 | — | — | 1 | 6.28 |
| CHEMBL448987 | — | — | 1 | 6.19 |
| CHEMBL482296 | — | — | 1 | 6.17 |
| CHEMBL480161 | — | — | 1 | 6.10 |
| CHEMBL482297 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524196 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL494262 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL521116 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL494261 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL482298 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL521112 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL448987 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL482296 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL480161 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL482297 | — | IC50 | = | 960.0 | nM | 6.02 |