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Assay Detail

CHEMBL1012503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli beta-lactamase ACC4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-lactamase ACC-4 (CHEMBL5305)
Type SINGLE PROTEIN
Organism Escherichia coli

Publication

Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.
Papagiannitsis CC, Tzouvelekis LS, Tzelepi E, Miriagou V.
Antimicrob Agents Chemother (2007) 51 : 3763 -3767
PubMed 17664321 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 6.69 7.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL891 CLOXACILLIN 4.0 1 7.58
CHEMBL158 AZTREONAM 4.0 1 7.50
CHEMBL333078 1 4.99
CHEMBL777 CLAVULANIC ACID 4.0 1 -
CHEMBL403 SULBACTAM 4.0 1 -
CHEMBL404 TAZOBACTAM 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL891 CLOXACILLIN IC50 = 26.0 nM 7.58
CHEMBL158 AZTREONAM IC50 = 32.0 nM 7.50
CHEMBL333078 IC50 = 10300.0 nM 4.99
CHEMBL777 CLAVULANIC ACID IC50 > 500000.0 nM -
CHEMBL403 SULBACTAM IC50 = 250000.0 nM -
CHEMBL404 TAZOBACTAM IC50 = 171000.0 nM -