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Assay Detail

CHEMBL1012638

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCMV AD169 infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human betaherpesvirus 5
Cell Type HEL
Confidence 1 — Organism
Curated By Autocuration

Target

Human betaherpesvirus 5 (CHEMBL371)
Type ORGANISM
Organism Human betaherpesvirus 5

Publication

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
De Castro S, García-Aparicio C, Andrei G, Snoeck R, Balzarini J, Camarasa MJ, Velázquez S.
J Med Chem (2009) 52 : 1582 -1591
PubMed 19226140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 37 5.11 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5314375 CIDOFOVIR 4.0 1 6.52
CHEMBL182 GANCICLOVIR 4.0 1 5.70
CHEMBL515379 1 5.19
CHEMBL459358 1 5.16
CHEMBL457456 1 5.14
CHEMBL517257 1 5.05
CHEMBL518659 1 5.00
CHEMBL461899 1 4.98
CHEMBL459802 1 4.92
CHEMBL514752 1 4.89
CHEMBL517555 1 4.82
CHEMBL457670 1 4.70
CHEMBL471632 1 4.30
CHEMBL511498 1 -
CHEMBL449381 1 -
CHEMBL510217 1 -
CHEMBL456014 1 -
CHEMBL456015 1 -
CHEMBL510218 1 -
CHEMBL456016 1 -
CHEMBL460199 1 -
CHEMBL456210 1 -
CHEMBL458745 1 -
CHEMBL458545 1 -
CHEMBL517856 1 -
CHEMBL459594 1 -
CHEMBL459798 1 -
CHEMBL517401 1 -
CHEMBL517548 1 -
CHEMBL460404 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5314375 CIDOFOVIR EC50 = 300.0 nM 6.52
CHEMBL182 GANCICLOVIR EC50 = 2000.0 nM 5.70
CHEMBL515379 EC50 = 6500.0 nM 5.19
CHEMBL459358 EC50 = 6900.0 nM 5.16
CHEMBL457456 EC50 = 7200.0 nM 5.14
CHEMBL517257 EC50 = 9000.0 nM 5.05
CHEMBL518659 EC50 = 10000.0 nM 5.00
CHEMBL461899 EC50 = 10400.0 nM 4.98
CHEMBL459802 EC50 = 12000.0 nM 4.92
CHEMBL514752 EC50 = 13000.0 nM 4.89
CHEMBL517555 EC50 = 15000.0 nM 4.82
CHEMBL457670 EC50 = 20000.0 nM 4.70
CHEMBL471632 EC50 = 50000.0 nM 4.30
CHEMBL456637 EC50 > 80000.0 nM -
CHEMBL513267 EC50 > 400000.0 nM -
CHEMBL508630 EC50 > 200000.0 nM -
CHEMBL458734 EC50 > 400000.0 nM -
CHEMBL458735 EC50 > 400000.0 nM -
CHEMBL456207 EC50 > 400000.0 nM -
CHEMBL506266 EC50 > 400000.0 nM -
CHEMBL511498 EC50 > 400000.0 nM -
CHEMBL449381 EC50 > 400000.0 nM -
CHEMBL510217 EC50 > 400000.0 nM -
CHEMBL456014 EC50 > 80000.0 nM -
CHEMBL456015 EC50 > 80000.0 nM -
CHEMBL510218 EC50 > 400000.0 nM -
CHEMBL456016 EC50 > 200000.0 nM -
CHEMBL460199 EC50 > 3200.0 nM -
CHEMBL456210 EC50 > 80000.0 nM -
CHEMBL458745 EC50 > 16000.0 nM -
CHEMBL458545 EC50 > 4000.0 nM -
CHEMBL517856 EC50 = 200000.0 nM -
CHEMBL459594 EC50 > 400000.0 nM -
CHEMBL459798 EC50 > 80000.0 nM -
CHEMBL517401 EC50 > 400000.0 nM -
CHEMBL517548 EC50 > 400000.0 nM -
CHEMBL460404 EC50 < 3200.0 nM -