Assay Detail
Binding
CHEMBL1012771
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Inhibition of 5-LO in PMNL cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PMNL |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.16 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29097 | — | — | 1 | 7.05 |
| CHEMBL314360 | — | — | 1 | 6.96 |
| CHEMBL456792 | — | — | 1 | 6.40 |
| CHEMBL463776 | — | — | 1 | 6.30 |
| CHEMBL459722 | — | — | 1 | 6.22 |
| CHEMBL460616 | — | — | 1 | 6.16 |
| CHEMBL462523 | — | — | 1 | 6.00 |
| CHEMBL457000 | — | — | 1 | 5.82 |
| CHEMBL518038 | — | — | 1 | 5.39 |
| CHEMBL455936 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29097 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL314360 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL456792 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL463776 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL459722 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL460616 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL462523 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL457000 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL518038 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL455936 | — | IC50 | = | 5000.0 | nM | 5.30 |