Assay Detail
Binding
CHEMBL1013071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of CGP-39653 from KA receptor in rat synaptosomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.22 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279561 | DIHYDROKAINATE | — | 1 | 5.22 |
| CHEMBL480169 | — | — | 1 | - |
| CHEMBL79140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279561 | DIHYDROKAINATE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL480169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL79140 | — | IC50 | = | 550000.0 | nM | - |