Assay Detail
Binding
CHEMBL1013119
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human c-RAF at 10 uM
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 9 | - | - |
| IC50 | 4 | 6.31 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430419 | — | — | 1 | 7.25 |
| CHEMBL303144 | — | — | 1 | 6.09 |
| CHEMBL67658 | — | — | 1 | 5.58 |
| CHEMBL494666 | — | — | 1 | - |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
| CHEMBL10 | SB-203580 | — | 1 | - |
| CHEMBL481943 | — | — | 1 | - |
| CHEMBL480952 | — | — | 1 | - |
| CHEMBL518964 | — | — | 1 | - |
| CHEMBL519617 | — | — | 1 | - |
| CHEMBL493669 | — | — | 1 | - |
| CHEMBL494871 | — | — | 1 | - |
| CHEMBL307435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430419 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL303144 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL67658 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL494666 | — | Inhibition | = | 31.0 | % | - |
| CHEMBL103667 | DORAMAPIMOD | Inhibition | = | 79.0 | % | - |
| CHEMBL10 | SB-203580 | Inhibition | = | 85.0 | % | - |
| CHEMBL481943 | — | Inhibition | = | - | % | - |
| CHEMBL480952 | — | Inhibition | = | - | % | - |
| CHEMBL518964 | — | Inhibition | = | 7.0 | % | - |
| CHEMBL519617 | — | Inhibition | = | 53.0 | % | - |
| CHEMBL493669 | — | Inhibition | = | 19.0 | % | - |
| CHEMBL494871 | — | Inhibition | = | 36.0 | % | - |
| CHEMBL307435 | — | IC50 | > | 1000.0 | nM | - |