Assay Detail
Binding
CHEMBL1013157
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 3H]paroxetine from rat cortical adrenergic alpha1 receptor
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.14 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519616 | — | — | 1 | 8.52 |
| CHEMBL481337 | — | — | 1 | 8.38 |
| CHEMBL520265 | — | — | 1 | 7.96 |
| CHEMBL481523 | — | — | 1 | 7.64 |
| CHEMBL494483 | — | — | 1 | 7.58 |
| CHEMBL517996 | — | — | 1 | 7.47 |
| CHEMBL518946 | — | — | 1 | 7.32 |
| CHEMBL481113 | — | — | 1 | 7.22 |
| CHEMBL494276 | — | — | 1 | 7.19 |
| CHEMBL481914 | — | — | 1 | 7.18 |
| CHEMBL481754 | — | — | 1 | 7.11 |
| CHEMBL481753 | — | — | 1 | 7.09 |
| CHEMBL481524 | — | — | 1 | 6.93 |
| CHEMBL481109 | — | — | 1 | 6.81 |
| CHEMBL481747 | — | — | 1 | 6.75 |
| CHEMBL359495 | — | — | 1 | 6.71 |
| CHEMBL522671 | — | — | 1 | 6.58 |
| CHEMBL520753 | — | — | 1 | 6.53 |
| CHEMBL480932 | — | — | 1 | 6.28 |
| CHEMBL493037 | — | — | 1 | 5.61 |
| CHEMBL481108 | — | — | 1 | - |
| CHEMBL482266 | — | — | 1 | - |
| CHEMBL479986 | — | — | 1 | - |
| CHEMBL481125 | — | — | 1 | - |
| CHEMBL481126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519616 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL481337 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL520265 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL481523 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL494483 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL517996 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL518946 | — | Ki | = | 47.6 | nM | 7.32 |
| CHEMBL481113 | — | Ki | = | 60.5 | nM | 7.22 |
| CHEMBL494276 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL481914 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL481754 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL481753 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL481524 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL481109 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL481747 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL359495 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL522671 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL520753 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL480932 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL493037 | — | Ki | = | 2430.0 | nM | 5.61 |
| CHEMBL481108 | — | Ki | - | — | - | |
| CHEMBL482266 | — | Ki | - | — | - | |
| CHEMBL479986 | — | Ki | - | — | - | |
| CHEMBL481125 | — | Ki | - | — | - | |
| CHEMBL481126 | — | Ki | - | — | - |