Assay Detail
Binding
CHEMBL1013486
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Inhibition of human erythrocytes mu-calpain
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.76 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195728 | — | — | 1 | 7.40 |
| CHEMBL423112 | — | — | 1 | 7.16 |
| CHEMBL458859 | — | — | 1 | 6.47 |
| CHEMBL467750 | — | — | 1 | 6.28 |
| CHEMBL460813 | — | — | 1 | 6.27 |
| CHEMBL459288 | — | — | 1 | 6.16 |
| CHEMBL254142 | — | — | 1 | 6.15 |
| CHEMBL462912 | — | — | 1 | 6.02 |
| CHEMBL457768 | — | — | 1 | 5.93 |
| CHEMBL465169 | — | — | 1 | 5.79 |
| CHEMBL465173 | — | — | 1 | 5.73 |
| CHEMBL461666 | — | — | 1 | 5.68 |
| CHEMBL499571 | — | — | 1 | 5.67 |
| CHEMBL464965 | — | — | 1 | 5.63 |
| CHEMBL466551 | — | — | 1 | 5.50 |
| CHEMBL518334 | — | — | 1 | 5.48 |
| CHEMBL457993 | — | — | 1 | 5.42 |
| CHEMBL464136 | — | — | 1 | 5.37 |
| CHEMBL461669 | — | — | 1 | 5.37 |
| CHEMBL457776 | — | — | 1 | 5.24 |
| CHEMBL514112 | — | — | 1 | 5.21 |
| CHEMBL466550 | — | — | 1 | 5.20 |
| CHEMBL465172 | — | — | 1 | 5.10 |
| CHEMBL503173 | — | — | 1 | 4.89 |
| CHEMBL457767 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195728 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL423112 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL458859 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL467750 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL460813 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL459288 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL254142 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL462912 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL457768 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL465169 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL465173 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL461666 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL499571 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL464965 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL466551 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL518334 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL457993 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL464136 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL461669 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL457776 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL514112 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL466550 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL465172 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL503173 | — | IC50 | = | 12990.0 | nM | 4.89 |
| CHEMBL457767 | — | IC50 | = | 13840.0 | nM | 4.86 |