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Assay Detail

CHEMBL1013531

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of BuChE from equine serum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Butyrylcholinesterase (CHEMBL5077)
Type SINGLE PROTEIN
Organism Equus caballus

Publication

NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.
Fang L, Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J.
J Med Chem (2008) 51 : 7666 -7669
PubMed 19053746 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.94 8.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL95 TACRINE 4.0 1 8.29
CHEMBL512550 1 8.14
CHEMBL444150 1 8.14
CHEMBL407320 1 8.00
CHEMBL458284 1 7.89
CHEMBL447441 1 7.88
CHEMBL269865 1 7.87
CHEMBL458486 1 7.84
CHEMBL516165 1 7.83
CHEMBL458487 1 7.77
CHEMBL456136 1 7.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL95 TACRINE IC50 = 5.1 nM 8.29
CHEMBL512550 IC50 = 7.3 nM 8.14
CHEMBL444150 IC50 = 7.2 nM 8.14
CHEMBL407320 IC50 = 9.9 nM 8.00
CHEMBL458284 IC50 = 12.9 nM 7.89
CHEMBL447441 IC50 = 13.3 nM 7.88
CHEMBL269865 IC50 = 13.5 nM 7.87
CHEMBL458486 IC50 = 14.3 nM 7.84
CHEMBL516165 IC50 = 14.8 nM 7.83
CHEMBL458487 IC50 = 17.0 nM 7.77
CHEMBL456136 IC50 = 18.1 nM 7.74