Assay Detail
Binding
CHEMBL1013543
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Binding affinity to galectin 9N terminal domain at 0 degC by fluorescence polarization assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 5.35 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444662 | — | — | 1 | 6.14 |
| CHEMBL509915 | — | — | 1 | 5.85 |
| CHEMBL457430 | — | — | 1 | 5.80 |
| CHEMBL503116 | — | — | 1 | 5.75 |
| CHEMBL458489 | — | — | 1 | 5.66 |
| CHEMBL443156 | — | — | 1 | 5.55 |
| CHEMBL457221 | — | — | 1 | 5.16 |
| CHEMBL509180 | — | — | 1 | 5.08 |
| CHEMBL505576 | — | — | 1 | 4.82 |
| CHEMBL5314358 | LACTOSE, ANHYDROUS | 3.0 | 1 | 4.64 |
| CHEMBL52011 | THIODIGALACTOSIDE | — | 1 | 4.42 |
| CHEMBL516152 | — | — | 1 | - |
| CHEMBL457432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444662 | — | Kd | = | 730.0 | nM | 6.14 |
| CHEMBL509915 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL457430 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL503116 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL458489 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL443156 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL457221 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL509180 | — | Kd | = | 8300.0 | nM | 5.08 |
| CHEMBL505576 | — | Kd | = | 15000.0 | nM | 4.82 |
| CHEMBL5314358 | LACTOSE, ANHYDROUS | Kd | = | 23000.0 | nM | 4.64 |
| CHEMBL52011 | THIODIGALACTOSIDE | Kd | = | 38000.0 | nM | 4.42 |
| CHEMBL516152 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL457432 | — | Kd | = | 490000.0 | nM | - |