Assay Detail
Binding
CHEMBL1013549
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Displacement of [3H]WIN-35428 from DAT
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.68 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457865 | — | — | 1 | 9.09 |
| CHEMBL459332 | — | — | 1 | 8.60 |
| CHEMBL514424 | — | — | 1 | 8.48 |
| CHEMBL457635 | — | — | 1 | 8.22 |
| CHEMBL457655 | — | — | 1 | 8.22 |
| CHEMBL512202 | — | — | 1 | 8.19 |
| CHEMBL458080 | — | — | 1 | 8.15 |
| CHEMBL455937 | — | — | 1 | 7.89 |
| CHEMBL515988 | — | — | 1 | 7.85 |
| CHEMBL516933 | — | — | 1 | 7.82 |
| CHEMBL458072 | — | — | 1 | 7.80 |
| CHEMBL461241 | — | — | 1 | 7.75 |
| CHEMBL457866 | — | — | 1 | 7.38 |
| CHEMBL513090 | — | — | 1 | 7.33 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | 4.0 | 1 | 7.05 |
| CHEMBL458282 | — | — | 1 | 7.04 |
| CHEMBL458488 | — | — | 1 | 7.04 |
| CHEMBL459333 | — | — | 1 | 6.99 |
| CHEMBL457415 | — | — | 1 | 6.77 |
| CHEMBL457416 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457865 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL459332 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL514424 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL457635 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL457655 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL512202 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL458080 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL455937 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL515988 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL516933 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL458072 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL461241 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL457866 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL513090 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL458282 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL458488 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL459333 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL457415 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL457416 | — | IC50 | = | 1300.0 | nM | 5.89 |