Assay Detail
Functional
CHEMBL1013705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus infected human 2209-23 cells by genotype 1b replicon assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | 2209-23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.23 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.70 |
| CHEMBL513181 | — | — | 1 | 6.77 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 5.89 |
| CHEMBL513182 | — | — | 1 | 4.56 |
| CHEMBL469096 | — | — | 1 | - |
| CHEMBL451080 | — | — | 1 | - |
| CHEMBL469095 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL513181 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL513182 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL469096 | — | IC50 | < | 100000.0 | nM | - |
| CHEMBL451080 | — | IC50 | < | 100000.0 | nM | - |
| CHEMBL469095 | — | IC50 | < | 100000.0 | nM | - |