Assay Detail
Binding
CHEMBL1013889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38 MAPK
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.72 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307435 | — | — | 1 | 9.96 |
| CHEMBL303144 | — | — | 1 | 9.72 |
| CHEMBL111456 | — | — | 1 | 8.40 |
| CHEMBL430419 | — | — | 1 | 7.32 |
| CHEMBL67658 | — | — | 1 | 7.07 |
| CHEMBL324977 | — | — | 1 | 6.66 |
| CHEMBL111364 | — | — | 1 | 6.42 |
| CHEMBL113419 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307435 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL303144 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL111456 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL430419 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL67658 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL324977 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL111364 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL113419 | — | IC50 | = | 630.0 | nM | 6.20 |