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Assay Detail

CHEMBL1014121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of G2 check point in gamma-irradiated human MCF7 cells expressing mutant p53 after 16 hrs by flow cytometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Challenges and rewards of research in marine natural products chemistry in Brazil.
Berlinck RG, Hajdu E, da Rocha RM, de Oliveira JH, Hernández IL, Seleghim MH, Granato AC, de Almeida EV, Nuñez CV, Muricy G, Peixinho S, Pessoa C, Moraes MO, Cavalcanti BC, Nascimento GG, Thiemann O, Silva M, Souza AO, Silva CL, Minarini PR.
J Nat Prod (2004) 67 : 510 -522
PubMed 15043447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL413188 ISOGRANULATIMIDE 1 6.00
CHEMBL240747 GRANULATIMIDE 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL413188 ISOGRANULATIMIDE IC50 = 1000.0 nM 6.00
CHEMBL240747 GRANULATIMIDE IC50 = 1000.0 nM 6.00