Assay Detail
Binding
CHEMBL1014187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 integrase 3' processing activity by PAGE
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.54 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464213 | — | — | 1 | 5.05 |
| CHEMBL50605 | — | — | 1 | 4.82 |
| CHEMBL464215 | — | — | 1 | 4.64 |
| CHEMBL464216 | — | — | 1 | 4.47 |
| CHEMBL197014 | — | — | 1 | 4.40 |
| CHEMBL464212 | — | — | 1 | 4.35 |
| CHEMBL511191 | — | — | 1 | 4.04 |
| CHEMBL464214 | — | — | 1 | - |
| CHEMBL463072 | — | — | 1 | - |
| CHEMBL513808 | — | — | 1 | - |
| CHEMBL464629 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464213 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL50605 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL464215 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL464216 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL197014 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL464212 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL511191 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL464214 | — | IC50 | = | 580000.0 | nM | - |
| CHEMBL463072 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL513808 | — | IC50 | = | 275000.0 | nM | - |
| CHEMBL464629 | — | IC50 | = | 800000.0 | nM | - |