Assay Detail
Functional
CHEMBL1014217
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Cytotoxicity against human MCF7 cells after 72 hrs in presence of NQO1 inhibitor dicoumarol
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.47 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511618 | — | — | 1 | 7.16 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.18 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511618 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL383824 | ALVESPIMYCIN | IC50 | = | 862.0 | nM | 6.06 |