Assay Detail
Binding
CHEMBL1014420
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Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.62 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462523 | — | — | 1 | 5.89 |
| CHEMBL460616 | — | — | 1 | 5.80 |
| CHEMBL457204 | — | — | 1 | 5.80 |
| CHEMBL456792 | — | — | 1 | 5.77 |
| CHEMBL463776 | — | — | 1 | 5.68 |
| CHEMBL29097 | — | — | 1 | 5.68 |
| CHEMBL456800 | — | — | 1 | 5.68 |
| CHEMBL457000 | — | — | 1 | 5.58 |
| CHEMBL518038 | — | — | 1 | 5.41 |
| CHEMBL455936 | — | — | 1 | 5.29 |
| CHEMBL459722 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462523 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL460616 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL457204 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL456792 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL463776 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL29097 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL456800 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL457000 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL518038 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL455936 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL459722 | — | IC50 | = | 5600.0 | nM | 5.25 |