Assay Detail
Functional
CHEMBL1014436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.01 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.40 |
| CHEMBL519586 | — | — | 1 | 8.54 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.48 |
| CHEMBL364123 | — | — | 1 | 8.34 |
| CHEMBL447657 | — | — | 1 | 8.09 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.96 |
| CHEMBL522086 | — | — | 1 | 7.19 |
| CHEMBL488269 | — | — | 1 | 7.14 |
| CHEMBL489276 | — | — | 1 | 6.56 |
| CHEMBL489078 | — | — | 1 | 6.42 |
| CHEMBL507585 | — | — | 1 | 6.29 |
| CHEMBL522766 | — | — | 1 | 6.22 |
| CHEMBL522254 | — | — | 1 | 6.00 |
| CHEMBL489275 | — | — | 1 | 6.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL522253 | — | — | 1 | 5.58 |
| CHEMBL489279 | — | — | 1 | 5.06 |
| CHEMBL489468 | — | — | 1 | - |
| CHEMBL489469 | — | — | 1 | - |
| CHEMBL489272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL519586 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL364123 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL447657 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL107 | COLCHICINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL522086 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL488269 | — | IC50 | = | 72.9 | nM | 7.14 |
| CHEMBL489276 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL489078 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL507585 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL522766 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL522254 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL489275 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL522253 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL489279 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL489468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489272 | — | IC50 | > | 10000.0 | nM | - |