Assay Detail
Functional
CHEMBL1014437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.51 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519586 | — | — | 1 | 8.48 |
| CHEMBL364123 | — | — | 1 | 8.21 |
| CHEMBL447657 | — | — | 1 | 7.96 |
| CHEMBL488269 | — | — | 1 | 7.24 |
| CHEMBL522086 | — | — | 1 | 7.16 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.04 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.94 |
| CHEMBL489276 | — | — | 1 | 6.58 |
| CHEMBL489078 | — | — | 1 | 6.44 |
| CHEMBL522766 | — | — | 1 | 6.29 |
| CHEMBL507585 | — | — | 1 | 6.28 |
| CHEMBL489275 | — | — | 1 | 6.04 |
| CHEMBL522254 | — | — | 1 | 5.96 |
| CHEMBL522253 | — | — | 1 | 5.61 |
| CHEMBL489279 | — | — | 1 | 5.10 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.78 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.64 |
| CHEMBL489468 | — | — | 1 | - |
| CHEMBL489469 | — | — | 1 | - |
| CHEMBL489272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519586 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL364123 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL447657 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL488269 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL522086 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 90.1 | nM | 7.04 |
| CHEMBL107 | COLCHICINE | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL489276 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL489078 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL522766 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL507585 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL489275 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL522254 | — | IC50 | = | 1104.0 | nM | 5.96 |
| CHEMBL522253 | — | IC50 | = | 2431.0 | nM | 5.61 |
| CHEMBL489279 | — | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL489468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489272 | — | IC50 | > | 10000.0 | nM | - |