Assay Detail
Functional
CHEMBL1014440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.88 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519586 | — | — | 1 | 8.68 |
| CHEMBL364123 | — | — | 1 | 8.49 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.89 |
| CHEMBL447657 | — | — | 1 | 7.68 |
| CHEMBL488269 | — | — | 1 | 7.36 |
| CHEMBL522086 | — | — | 1 | 7.28 |
| CHEMBL489276 | — | — | 1 | 6.59 |
| CHEMBL522766 | — | — | 1 | 6.50 |
| CHEMBL489078 | — | — | 1 | 6.47 |
| CHEMBL507585 | — | — | 1 | 6.33 |
| CHEMBL522254 | — | — | 1 | 6.08 |
| CHEMBL489275 | — | — | 1 | 6.06 |
| CHEMBL522253 | — | — | 1 | 5.75 |
| CHEMBL489279 | — | — | 1 | 5.13 |
| CHEMBL489272 | — | — | 1 | - |
| CHEMBL489468 | — | — | 1 | - |
| CHEMBL489469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519586 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL364123 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL447657 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL488269 | — | IC50 | = | 44.1 | nM | 7.36 |
| CHEMBL522086 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL489276 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL522766 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL489078 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL507585 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL522254 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL489275 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL522253 | — | IC50 | = | 1762.0 | nM | 5.75 |
| CHEMBL489279 | — | IC50 | = | 7432.0 | nM | 5.13 |
| CHEMBL489272 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489469 | — | IC50 | > | 10000.0 | nM | - |