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Assay Detail

CHEMBL1014493

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Rew Y, McMinn DL, Wang Z, He X, Hungate RW, Jaen JC, Sudom A, Sun D, Tu H, Ursu S, Villemure E, Walker NP, Yan X, Ye Q, Powers JP.
Bioorg Med Chem Lett (2009) 19 : 1797 -1801
PubMed 19217779 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.37 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL452587 1 8.60
CHEMBL491326 1 8.40
CHEMBL454620 1 8.10
CHEMBL2021494 1 -
CHEMBL2021501 1 -
CHEMBL512355 1 -
CHEMBL489320 1 -
CHEMBL508331 1 -
CHEMBL523600 1 -
CHEMBL491327 1 -
CHEMBL2021502 1 -
CHEMBL2021493 1 -
CHEMBL507804 1 -
CHEMBL454621 1 -
CHEMBL453620 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL452587 IC50 = 2.5 nM 8.60
CHEMBL491326 IC50 = 4.0 nM 8.40
CHEMBL454620 IC50 = 8.0 nM 8.10
CHEMBL2021494 IC50 - -
CHEMBL2021501 IC50 - -
CHEMBL512355 IC50 > 10.0 nM -
CHEMBL489320 IC50 > 10.0 nM -
CHEMBL508331 IC50 - -
CHEMBL523600 IC50 - -
CHEMBL491327 IC50 - -
CHEMBL2021502 IC50 > 10.0 nM -
CHEMBL2021493 IC50 > 10.0 nM -
CHEMBL507804 IC50 > 10.0 nM -
CHEMBL454621 IC50 > 10.0 nM -
CHEMBL453620 IC50 > 10.0 nM -