Assay Detail
Binding
CHEMBL1014536
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Displacement of [35S]TBPS from Wistar rat brain GABAA receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) derivatives with a polar chain in position 16alpha: synthesis and activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.87 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515590 | — | — | 1 | 7.40 |
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 7.10 |
| CHEMBL474985 | — | — | 1 | 7.07 |
| CHEMBL1094 | FELBAMATE | 4.0 | 1 | 7.02 |
| CHEMBL522179 | — | — | 1 | 6.52 |
| CHEMBL493339 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515590 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL207538 | BREXANOLONE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL474985 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1094 | FELBAMATE | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL522179 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL493339 | — | IC50 | = | 750.0 | nM | 6.12 |