Assay Detail
Binding
CHEMBL1014547
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Binding affinity to human NTR1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.31 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342252 | — | — | 1 | 9.85 |
| CHEMBL453924 | — | — | 1 | 8.35 |
| CHEMBL499673 | — | — | 1 | 8.00 |
| CHEMBL266571 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342252 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL453924 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL499673 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL266571 | — | Ki | = | 95.0 | nM | 7.02 |