Assay Detail
Binding
CHEMBL1014617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]leucine from Large neutral amino acids transporter system L in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxadiazolone bioisosteres of pregabalin and gabapentin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL940 | GABAPENTIN | 4.0 | 1 | 4.52 |
| CHEMBL1059 | PREGABALIN | 4.0 | 1 | - |
| CHEMBL258019 | — | — | 1 | - |
| CHEMBL404384 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL940 | GABAPENTIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1059 | PREGABALIN | IC50 | = | 158000.0 | nM | - |
| CHEMBL258019 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL404384 | — | IC50 | > | 10000000.0 | nM | - |