Assay Detail
Functional
CHEMBL1014859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KCl-induced increase in intracellular calcium level pretreated for 3 mins before KCl challenge
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and Ca++ channel blocker activity of crambescidin 816.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.87 | 9.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507597 | CRAMBESCIDIN 816 HYDROCHLORIDE | — | 2 | 9.82 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507597 | CRAMBESCIDIN 816 HYDROCHLORIDE | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL507597 | CRAMBESCIDIN 816 HYDROCHLORIDE | Activity | - | — | - |