Assay Detail
Binding
CHEMBL1014873
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Inhibition of human recombinant IMPDH assessed as NADH formation by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Isorawsonol and related IMP dehydrogenase inhibitors from the tropical green alga Avrainvillea rawsonii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.96 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460227 | ISORAWSONOL | — | 1 | 5.13 |
| CHEMBL518631 | RAWSONOL | — | 1 | 5.00 |
| CHEMBL460434 | AVRAINVILLEOL | — | 1 | 4.75 |
| CHEMBL460435 | AVRAINVILLEOL METHYL ETHER | — | 1 | - |
| CHEMBL451595 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460227 | ISORAWSONOL | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL518631 | RAWSONOL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL460434 | AVRAINVILLEOL | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL460435 | AVRAINVILLEOL METHYL ETHER | IC50 | - | — | - | |
| CHEMBL451595 | — | IC50 | - | — | - |