Assay Detail
Binding
CHEMBL1015016
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Binding affinity to human recombinant Hsp90alpha N-terminal domain by scintillation proximity assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.57 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511618 | — | — | 1 | 7.30 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 6.30 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.12 |
| CHEMBL517853 | — | — | 1 | - |
| CHEMBL469932 | — | — | 1 | - |
| CHEMBL512489 | — | — | 1 | - |
| CHEMBL511439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511618 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL383824 | ALVESPIMYCIN | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL109480 | TANESPIMYCIN | Kd | = | 760.0 | nM | 6.12 |
| CHEMBL517853 | — | Kd | - | — | - | |
| CHEMBL469932 | — | Kd | - | — | - | |
| CHEMBL512489 | — | Kd | - | — | - | |
| CHEMBL511439 | — | Kd | - | — | - |