Assay Detail
Binding
CHEMBL1015017
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Binding affinity to human recombinant Hsp90alpha N-terminal domain by isothermal titration calorimetry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.97 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512489 | — | — | 1 | 9.10 |
| CHEMBL511439 | — | — | 1 | 8.60 |
| CHEMBL469932 | — | — | 1 | 8.27 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 7.06 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.80 |
| CHEMBL511618 | — | — | 1 | - |
| CHEMBL517853 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512489 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL511439 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL469932 | — | Kd | = | 5.4 | nM | 8.27 |
| CHEMBL383824 | ALVESPIMYCIN | Kd | = | 87.0 | nM | 7.06 |
| CHEMBL109480 | TANESPIMYCIN | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL511618 | — | Kd | - | — | - | |
| CHEMBL517853 | — | Kd | - | — | - |