Assay Detail
Binding
CHEMBL1015211
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Inhibition of heme oxygenase-2 in Sprague-Dawley rat brain microsomal fraction assessed as carbon monoxide formation by gas chromatography
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Microsomal |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.95 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472795 | — | — | 1 | 6.30 |
| CHEMBL474379 | — | — | 1 | 5.77 |
| CHEMBL515086 | — | — | 1 | 5.62 |
| CHEMBL474359 | — | — | 1 | 5.60 |
| CHEMBL459480 | — | — | 1 | 5.48 |
| CHEMBL464300 | — | — | 1 | 5.36 |
| CHEMBL474555 | — | — | 1 | 5.30 |
| CHEMBL179494 | — | — | 1 | 5.22 |
| CHEMBL208047 | — | — | 1 | 5.16 |
| CHEMBL473375 | — | — | 1 | 5.15 |
| CHEMBL421109 | — | — | 1 | 5.10 |
| CHEMBL474360 | — | — | 1 | 4.92 |
| CHEMBL514775 | — | — | 1 | 4.91 |
| CHEMBL473364 | — | — | 1 | 4.89 |
| CHEMBL473177 | — | — | 1 | 4.89 |
| CHEMBL474961 | — | — | 1 | 4.82 |
| CHEMBL473167 | — | — | 1 | 4.80 |
| CHEMBL516227 | — | — | 1 | 4.72 |
| CHEMBL447959 | — | — | 1 | 4.72 |
| CHEMBL514329 | — | — | 1 | 4.72 |
| CHEMBL516064 | — | — | 1 | 4.66 |
| CHEMBL472782 | — | — | 1 | 4.66 |
| CHEMBL459907 | — | — | 1 | 4.58 |
| CHEMBL472975 | — | — | 1 | 4.52 |
| CHEMBL475163 | — | — | 1 | 4.47 |
| CHEMBL460114 | — | — | 1 | 4.42 |
| CHEMBL368045 | — | — | 1 | 4.38 |
| CHEMBL472796 | — | — | 1 | 4.37 |
| CHEMBL3216038 | — | — | 1 | 4.16 |
| CHEMBL515233 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472795 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL474379 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL515086 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL474359 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL459480 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL464300 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL474555 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL179494 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL208047 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL473375 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL421109 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL474360 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL514775 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL473364 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL473177 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL474961 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL473167 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL516227 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL514329 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL447959 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL516064 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL472782 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL459907 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL472975 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL475163 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL460114 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL368045 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL472796 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3216038 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL515233 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL474572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459908 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL460115 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL463223 | — | IC50 | = | 305000.0 | nM | - |