Assay Detail
Binding
CHEMBL1015237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.58 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.89 |
| CHEMBL519586 | — | — | 1 | 5.62 |
| CHEMBL447657 | — | — | 1 | 5.58 |
| CHEMBL522086 | — | — | 1 | 5.57 |
| CHEMBL364123 | — | — | 1 | 5.55 |
| CHEMBL489276 | — | — | 1 | 5.54 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.50 |
| CHEMBL488269 | — | — | 1 | 5.37 |
| CHEMBL489279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL519586 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL447657 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL522086 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL364123 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL489276 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL107 | COLCHICINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL488269 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL489279 | — | IC50 | > | 10000.0 | nM | - |