Assay Detail
Functional
CHEMBL1015292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MrgX1 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X1 (CHEMBL5850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.34 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502132 | — | — | 1 | 7.20 |
| CHEMBL505263 | — | — | 1 | 6.70 |
| CHEMBL466116 | — | — | 1 | 6.50 |
| CHEMBL503202 | — | — | 1 | 6.50 |
| CHEMBL501027 | — | — | 1 | 6.20 |
| CHEMBL506128 | — | — | 1 | 6.10 |
| CHEMBL474761 | — | — | 1 | 5.90 |
| CHEMBL504032 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502132 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL505263 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL466116 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL503202 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL501027 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL506128 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL474761 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL504032 | — | EC50 | = | 2511.89 | nM | 5.60 |