Assay Detail
Functional
CHEMBL1015296
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Agonist activity at monkey MrgX1 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca mulatta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.83 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503202 | — | — | 1 | 6.40 |
| CHEMBL502132 | — | — | 1 | 6.10 |
| CHEMBL505263 | — | — | 1 | 6.10 |
| CHEMBL466116 | — | — | 1 | 6.10 |
| CHEMBL474761 | — | — | 1 | 6.00 |
| CHEMBL501027 | — | — | 1 | 5.80 |
| CHEMBL504032 | — | — | 1 | 5.60 |
| CHEMBL506128 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503202 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL502132 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL505263 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL466116 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL474761 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL501027 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL504032 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL506128 | — | EC50 | = | 31622.78 | nM | 4.50 |