Assay Detail
Binding
CHEMBL1015470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1/2 from human HeLa cells nuclear extract by cell free fluorimetric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Histone deacetylase (HDAC1 and HDAC2) (CHEMBL2111429) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Non-peptide macrocyclic histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.28 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472250 | — | — | 1 | 8.72 |
| CHEMBL455735 | — | — | 1 | 8.39 |
| CHEMBL504040 | — | — | 1 | 7.97 |
| CHEMBL506834 | — | — | 1 | 7.86 |
| CHEMBL498908 | — | — | 1 | 7.43 |
| CHEMBL501640 | — | — | 1 | 7.35 |
| CHEMBL502430 | — | — | 1 | 7.25 |
| CHEMBL455342 | — | — | 1 | 7.23 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.19 |
| CHEMBL507617 | — | — | 1 | 7.14 |
| CHEMBL490446 | — | — | 1 | 7.05 |
| CHEMBL446811 | — | — | 1 | 7.04 |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | — | 1 | 6.97 |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | — | 1 | 6.96 |
| CHEMBL503113 | — | — | 1 | 6.91 |
| CHEMBL509089 | — | — | 1 | 6.84 |
| CHEMBL499994 | — | — | 1 | 6.77 |
| CHEMBL452168 | — | — | 1 | 6.65 |
| CHEMBL496761 | — | — | 1 | 6.64 |
| CHEMBL505410 | AZITHROMYCINARYLALKYL METHYL ESTER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472250 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL455735 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL504040 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL506834 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL498908 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL501640 | — | IC50 | = | 44.3 | nM | 7.35 |
| CHEMBL502430 | — | IC50 | = | 55.6 | nM | 7.25 |
| CHEMBL455342 | — | IC50 | = | 58.9 | nM | 7.23 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL507617 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL490446 | — | IC50 | = | 88.8 | nM | 7.05 |
| CHEMBL446811 | — | IC50 | = | 91.6 | nM | 7.04 |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | IC50 | = | 107.1 | nM | 6.97 |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | IC50 | = | 109.8 | nM | 6.96 |
| CHEMBL503113 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL509089 | — | IC50 | = | 145.5 | nM | 6.84 |
| CHEMBL499994 | — | IC50 | = | 169.8 | nM | 6.77 |
| CHEMBL452168 | — | IC50 | = | 223.4 | nM | 6.65 |
| CHEMBL496761 | — | IC50 | = | 226.7 | nM | 6.64 |
| CHEMBL505410 | AZITHROMYCINARYLALKYL METHYL ESTER | IC50 | - | — | - |