Assay Detail
Binding
CHEMBL1015473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 from human HeLa cells nuclear extract by cell free fluorimetric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-peptide macrocyclic histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.00 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506834 | — | — | 1 | 7.11 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.07 |
| CHEMBL455735 | — | — | 1 | 7.05 |
| CHEMBL504040 | — | — | 1 | 6.93 |
| CHEMBL472250 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506834 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 85.5 | nM | 7.07 |
| CHEMBL455735 | — | IC50 | = | 89.3 | nM | 7.05 |
| CHEMBL504040 | — | IC50 | = | 117.4 | nM | 6.93 |
| CHEMBL472250 | — | IC50 | = | 148.5 | nM | 6.83 |