Assay Detail
Functional
CHEMBL1015475
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Cytotoxicity against human SKMES1 cells after 72 hrs by trypan blue exclusion assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MES-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Non-peptide macrocyclic histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.54 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472250 | — | — | 1 | 5.89 |
| CHEMBL455735 | — | — | 1 | 5.88 |
| CHEMBL490446 | — | — | 1 | 5.78 |
| CHEMBL446811 | — | — | 1 | 5.75 |
| CHEMBL501640 | — | — | 1 | 5.71 |
| CHEMBL498908 | — | — | 1 | 5.67 |
| CHEMBL506834 | — | — | 1 | 5.63 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.62 |
| CHEMBL504040 | — | — | 1 | 5.59 |
| CHEMBL503113 | — | — | 1 | 5.35 |
| CHEMBL507617 | — | — | 1 | 5.33 |
| CHEMBL455342 | — | — | 1 | 5.31 |
| CHEMBL502430 | — | — | 1 | 5.31 |
| CHEMBL499994 | — | — | 1 | 5.15 |
| CHEMBL509089 | — | — | 1 | 5.12 |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | — | 1 | - |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472250 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL455735 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL490446 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL446811 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL501640 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL498908 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL506834 | — | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL504040 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL503113 | — | EC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL507617 | — | EC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL455342 | — | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL502430 | — | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL499994 | — | EC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL509089 | — | EC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | EC50 | - | — | - | |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | EC50 | - | — | - |